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Antipsychotic dose: from research to clinical practice

St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE

Sean McGuigan, Formerly Head of Biostatistics Department

Department of Mental Health Sciences, St. George's Hospital Medical School

^* Correspondence

A case note study of antipsychotic prescribing in an inner London hospital showed that although doses of individual drugs were below the British National Formulary limits, polypharmacy occurred in a third of cases. Multiple regression analysis showed high doses were associated with a current risk to the self or others and increasing number of previous admissions in patients with mania and treatment non-responsiveness in schizophrenia.

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