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A dedicated nurse-led service for antipsychotic-induced weight gain

An evaluation

Section of Neurochemical Imaging and Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF and Maudsley Hospital, London SE5 8AZ

Correspondence: E-mail: r.ohlsen{at}iop.kcl.ac.uk

AIMS AND METHOD

To evaluate a psychosocial intervention for patients treated with antipsychotics with body mass index (BMI) >25. A total of 44 patients (mean age (s.e.) 37.6 (1.2); 28 female, 16 male) received dietary and exercise advice with motivational interviewing. Weight and BMI were measured at baseline and monthly thereafter. Patients were offered weight monitoring for 1 year.

RESULTS

Overall mean weight loss was 3.1 kg (mean 3.22%). Modal (range) weight change was -4.2 (-19.2 kg to +8.7 kg).

CLINICAL IMPLICATIONS

Overall weight loss was not significant after 355.7 (32.5) (mean, s.e.) days. Determinants of response remain unclear. Avoiding weight gain in the first instance is critical. Further research will explore determinants of antipsychotic-induced weight gain and prevention strategies.