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Psychiatric Bulletin (2007) 31: 191. doi: 10.1192/pb.31.5.191a
© 2007 The Royal College of Psychiatrists
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Correspondence

Clozapine-induced speech dysfluency: further cases

Nasser Abdelmawla

Brandon Mental Health Unit, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, email: Nasser.Abdelmawla{at}leics.part.nhs.uk

Stephen J. Frost

Brandon Mental Health Unit, Leicester General Hospital

Lyall et al (Psychiatric Bulletin, January 2007, 31, 16-18) presented two cases of clozapine-induced speech dysfluency and suggest that there are only four cases in the British and American literature. However, we do not think that their literature search was comprehensive. Begum (2005) reported stuttering, facial tics and myoclonic seizures, which developed a few days after initiation of clozapine for treatment-resistant schizophrenia. Furthermore, Bär et al (2004) examined the hospital records of about 6000 German patients receiving antipsychotic treatment over 3 years for evidence of stuttering as a possible side-effect. They described seven patients with stuttering induced by the atypical antipsychotics olanzapine (six cases), and clozapine (one case).

We also observed a man in his early 40s who developed stuttering when his clozapine was increased from 400 mg/day to 450 mg/day. This was also associated with a marked increase in seizure activity which necessitated reducing and stopping clozapine.

We suggest that future case reports in the Psychiatric Bulletin should describe a systematic search of standard databases for other case reports and the time period covered by such a search. This would be beneficial to the Psychiatric Bulletin and the wider readership.

References

BÄR, K. J., HÄGER, F. & SAUER, H. (2004) Olanzapine- and clozapine-induced stuttering: a case series. Pharmacopsychiatry, 37, 131 -134.[CrossRef][Medline]

BEGUM, M. (2005) Clozapine-induced stuttering, facial tics and myoclonic seizures: a case report. Australian and New Zealand Journal of Psychiatry, 39, 202 .[Medline]





This Article
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Right arrow Articles by Frost, S. J.

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